The Upjohn Co.

Pharmacia & Upjohn Company

Other

Alcon Laboratories, Inc.

Paul A Aristoff

Harvey I Skulnick

Suvit Thaisrivongs

Gordon L Bundy

Ruben Alberto Tommasi

Paul D Johnson

Robert C Kelly

Joseph Walter Strohbach

Ronald B Gammill

David John Anderson

Steven Ronald Turner

Karen Rene Romines

John C Sih

Donna Lee Romero

Richard Charles Thomas

John R Palmer

Joel Morris

Louis L Skaletzky

W Jeffrey Howe

Linda Louise Maggiora

Clark W Smith

Theresa M Schwartz

George P Luke

James M Tustin

Herman W Smith

Wendell Wierenga

Robert Alan Chrusciel

Toni-Jo Poel

Mark Allen Mitchell

Lisa Marie Thomasco

David G Martin

Paul K Tomich

Michael John Bohanon

Chih-Ping Yang

Lee S Banitt

Qingwei Zhang

John W Wilks

Thomas F DeKoning

Robert A Chruscial

The present invention provides oxazolidinones having a benzannelated 6- or 7-membered heterocycle as antibacterial agents.

Oxazolidinones having a benzannulated 6-  or 7-membered heterocycle

The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl&lsqb;b&rsqb;pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.

Compounds useful to treat retroviral infections

Substituted tetronic acids useful for treating HIV and other retroviruses

Novel angiostatic .DELTA..sup.4,9(11) -steroids (I), ##STR1## C.sub.21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids are useful in treating diseases of neovascularization such as cancer, diabetes and arthritis.

Steroids which inhibit angiogenesis

Pyranone compounds useful to treat retroviral infections

This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests. In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.

CC-1065 analogs

4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl�b!pyran-2-ones

The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus.

Diaromatic substituted compounds as anti-HIV-1 agents

CC-1065 analogs having two CPI subunits

The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).

Anti-aids piperazines

This invention concerns 2-acyl-4,5,8,8a-tetrahydro-4-oxycyclopropan[c]pyrrol(3,2-e) indole derivatives of Formula I': ##STR1## the compounds of Formula I' are useful as uv light absorber substances, as chemical intermediates and as prodrugs of known spirocyclopropylpyrroloindole CC-1065 analogs. Representative Formula I' compounds have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.

Fluorinated flavone acetic acid

Disclosed are .DELTA..sup.9(11) -steroids of the formula ##STR1## which have been found to be angiostatic and therefore are useful in the control of embryogenesis, inflammatory conditions, tumor growth as well as other abnormalities.

.DELTA..sup.9(11) -angiostatic steroids

A compound of the formula ##STR1## and intermediates useful in preparing same.

Interphenylene carbacyclin derivatives

Growing community of inventors

Portage, MI, United States of America

Paul A Aristoff