Imperial College Innovations Limited

Gene Onyx Limited

Pau Herrero Vinas

Christofer Toumazou

Pantelis Georgiou

Nick Oliver

Calvin Sim

A method of adaptively determining one or more compensation factors in a closed-loop insulin delivery system comprising a continuous glucose level sensor, an insulin pump, and an insulin reservoir, where the system determines an insulin meal bolus taking into account an estimated amount of carbohydrates to be ingested, CHO, a difference between a currently sensed glucose level, G, and a glucose set point, G, and at least one compensation factor, ICR. The method comprises

Automatic closed-loop glucose control with an adaptive meal bolus calculator

The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimizing the gain factor based on the historical data in relation to the patient.

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Pau Herrero Vinas