Eli Lilly and Company

Dow Agrosciences LLC

Other

Patti J Treadway

Richard H Baltz

Paul Luther Skatrud

Patricia J Solenberg

Jo Ann Hoskins

Donald J Merlo

Robert Brown Peery

Jan R Turner

Clive Waldron

M Christine Broughton

Kathryn P Crawford

Krishnamurthy Madduri

Pamela Kay Rockey

Michele Louise Young Bellido

Joseph Chiou-Chung Tang

Franklin H Norris

Chyun-Yeh Earnest Wu

Paul R Rosteck, Jr

R Nagaraja Rao

Genshi Zhao

Richard K Stanzak

Stanley Richard Jaskunas, Jr

Michele Louise Bellido

Paul Robert Rosteck, Jr

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme ofAlso provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

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Spinosyn biosynthetic genes fromspinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.

DNA encoding SPNF of the spinosyn cluster

The invention provides isolated nucleic acid compounds encoding the 454 gene of . Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene HI0454

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of . Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

Glycosyltransferase gene gtfE from Amycolatopsis oreintalis

Spinosyn biosynthetic genes from , spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.

SpnG, a gene for spinosyn insecticide biosynthesis

The invention provides isolated nucleic acid compounds encoding GrpE of Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae sequence GrpE

The invention provides isolated nucleic acid compounds encoding HI1648 of Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence HI1648

Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.

Biosynthetic genes for spinosyn insecticide production

The invention provides isolated nucleic acid compounds encoding gcp of,. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence GCP

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of,Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

Glucosyltransferase gene gtfe from Amycolatopsis orientalis

The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of,Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

Muri protein from Streptococcus pneumoniae

The invention provides isolated nucleic acid compounds encoding HI1146 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence HI1146

The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence Dpj

Provided herein is a method to produce knockout mutations at targeted sites in the genome of Streptococcus pneumoniae.

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Greenwood, IN, United States of America

Patti J Treadway