Bayer Schering Pharma Ag

Philogen S.p.a.

Sirius-Biotech S.r.l.

Patrizia Castellani

Laura Borsi

Enrica Balza

Matthias Friebe

Christoph-Stephan Hilger

Luciano Zardi

Barbara Carnemolla

Francesca Sassi

M Barbara Carnemolla

Epitopes localized on FNIII-repeat that are normally cryptic but are unmasked by insertion of FNIII-B into the FN molecule and are recognized by specific ligands are described; antibodies or their fragments able to identify the above said epitope are also described.

Monoclonal antibody and its use for the identification of the oncofetal isoform of fibronectin (B-FN) for diagnosis or therapy

The present invention relates to selectively targeting tumoral vasculature in vivo using a human recombinant scFv, L19, to the angiogenesis marker ED-B domain of fibronectin. In preferred embodiments, a complete human IgG1 is employed having the variable regions of L19. In other preferred embodiments is employed a mini-immunoglobulin generated by fusing the scFv L19 to the constant CH4 domain of a secretory IgE isoform that naturally contains a cysteine in its COOH terminal and which forms a covalently linked dimer. Different in vivo behavior of the antibody formats is exploitable for different diagnostic and/or therapeutic purposes, depending on clinical needs and disease. The antibody molecules may be labelled as described.

Selective targeting of tumor vasculature using antibody molecules

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Genoa, Italy

Patrizia Castellani