Vib Vzw

Katholieke Universiteit Leuven

Katholieke Universiteit Leuven, Ku Leuven R&d

Vrije Universiteit Brussel

Patrik Verstreken

Vanessa Morais Epifânio

Bart De Strooper

Lujia Zhou

Wim Annaert

Joseph McInnes

Melissa Vos

Sebastian Munck

Wim Versées

Baptiste Fischer

Kevin Lüthy

Jone Paesmans

The invention relates to identification of synaptogyrin-3 as a target for treating or inhibiting progression of tauopathies or symptoms of tauopathies. In particular, synaptogyrin-3 inhibitors for use as a medicament in general, and for treating or inhibiting progression of tauopathies or symptoms of tauopathies are envisaged. The invention further relates to methods for identification of or for screening for inhibitors of synaptogyrin-3.

Targeting synaptogyrin-3 in tauopathy treatment

This application relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular, the disclosure describes that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular, the treatment of patients suffering from Parkinson's disease having loss of function mutations in PINK1 or PARKIN genes.

Means and methods for treatment of early-onset Parkinson's disease

The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.

Restoring phosphorylation of a novel PINK1 substrate to treat parkinson's disease

A method and apparatus for the imaging of a labeled biological sample. The method comprises illuminating the labeled biological sample, generating members of a time series of images if the labeled biological sample, generating a plurality of difference images between later members of the time series of images of earlier members of the time series of images and combining the plurality of difference images to generate a final image of the labeled biological sample.

Method and apparatus for the imaging of a labeled biological sample

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Blanden, Belgium

Patrik Verstreken