Alexza Pharmaceuticals, Inc.

Patrik Munzar

Ron L Hale

Joshua D Rabinowitz

Dennis Solas

Peter Lloyd

Krishnamohan Sharma

Mingzu Lei

Matthew D Stracker

Loxapine, amoxapine, or salts or prodrugs of either, is effective in alleviating pain, particularly headache pain such as migraine, cluster headaches and tension headaches. Preferably the loxapine or amoxapine is administered systemically, most preferably by inhalation.

Method for treating headache with loxapine

Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.

Aerosol drug delivery device incorporating percussively activated heat packages

Growing community of inventors

Belmont, CA, United States of America

Patrik Munzar