Bristol-myers Squibb Compnay

Bristol-myers Squibb Pharma Company

The Dupont Merck Pharmaceutical Company

Dupont Pharmaceuticals Company

Other

Patrick Y Lam

Mimi Lifen Quan

John Matthew Fevig

Qi Han

James Russell Pruitt

Celia Dominguez

Charles G Clark

Donald J P Pinto

Renhua Li

Prabhakar Kondaji Jadhav

Carl Nicholas Hodge

Robert A Galemmo, Jr

James David Rodgers

Donald J Pinto

George Vincent De Lucca

Charles Joseph Eyermann

Christina Howard Fernandez

Karen Anita Rossi

Amy Han

Tasir Shamsul Haque

Thomas E Richardson

The present application describes pyrazolobenzamides and derivatives thereof of Formula I:P-P-M-MIor pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Pyrazolobenzamides and derivatives as factor Xa inhibitors

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.

Guanidine mimics as factor Xa inhibitors

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I:or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.

Guanidine mimics factor Xa inhibitors

Imidazo-heterobicycles as factor Xa inhibitors

Inhibitors of factor Xa with a neutral P1 specificity group

The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.

This invention relates to novel substituted caprolactams, including 4-azacaprolactams, and derivatives thereof which inhibit HIV protease and are useful for treatment of HIV disease. Also included in this invention are pharmaceutical compositions containing such caprolactams, and to methods of using such caprolactams for the treatment of HIV disease.

Substitute caprolactams and derivatives thereof useful for treatment of

This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: ##STR1## wherein R.sup.22 and R.sup.23 are allyl.

Substituted cyclic carbonyls and derivatives thereof useful as

Substituted 1,4-diazapine caprolactams useful for treatment of HIV

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Chadds Ford, PA, United States of America

Patrick Y Lam