Janssen Biotech, Inc.

Patrick Wilkinson

Ricardo Attar

Selina Khan

Manuel Sepulveda

Vinod Krishna

Jason DeHart

Christian Maine

Roland Zahn

Barbara Sanders

Jenifer Lum

Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.

Vaccines based on mutant CALR and JAK2 and their uses

Growing community of inventors

Collegeville, PA, United States of America

Patrick Wilkinson