Cryovac, Inc.

Patrick Wayne Thompson

Walter B Mueller

Solomon Bekele

The presently disclosed subject matter is directed to a polymeric films suitable for use in a wide variety of applications, including (but not limited to) the formation of bioprocessing containers. Particularly, the disclosed films comprise a first barrier layer comprising polyglycolic acid, polyamide, EVOH, and/or an EVOH blend and a second barrier layer comprising EVOH. The dual barrier layers of the film maintain a high gas barrier under a variety of relative humidity conditions. In addition, the disclosed film is biologically inert and free from film surface-modifying additives such that the film does not inhibit the growth of biological cell cultures.

Polymeric film for use in bioprocessing applications

The presently disclosed subject matter is directed to a barrier film that maintains an oxygen barrier after being subjected to autoclaving conditions. The film comprises one EVOH layer positioned as a core layer, and one EVOH layer positioned directly adjacent to an outer layer comprising highly permeable material having a moisture vapor permeability greater than about 40 g-mil/100 in-day-atm. During autoclaving, the barrier properties of the EVOH layer positioned adjacent to the outer layer allows improved recovery of oxygen barrier properties. In addition, during rewetting applications, the internal EVOH layer maintains the oxygen barrier. Also disclosed are methods of making and using the disclosed barrier film.

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Greenville, SC, United States of America

Patrick Wayne Thompson