University of California

Magnetic Insight, Inc.

Patrick W Goodwill

Steven M Conolly

Bo Zheng

Daniel Hensley

Zhi Wei Tay

Kyle David Fields

Elaine Yuiyi Yu

Robert Blayne Kettlewell

Daniel Westbrook Hensley

Matthias Weber

Steven M Gonolly

A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion.

Pulsed magnetic particle imaging systems and methods

Magnetic particle actuating systems may include a magnet system configured to generate a magnetic field that includes a field-free region. A corresponding control system can be configured to control the magnet system to create a field-free region at least partially matching a target region. An excitation system can be configured to generate an excitation field to cause actuation of magnetic nanoparticles in an actuation region.

Magnetic particle actuation

A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field with a field free line, the magnet integrated with a flux return designed so that a flux path at approximately the center of the field-free line has a first reluctance and a second flux path distal from the center of the field-free line has a second reluctance, and the second reluctance is lower than the first reluctance to facilitate a high fidelity magnetic field and high fidelity field free line.

Magnetic particle imaging

A magnetic particle imaging apparatus includes magnets [] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scamled to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.

Techniques for magnetic particle imaging

A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field having a field free line, the system including at least one shim magnet configured to modify the magnetic field in a manner to maintain desired magnetic flux distributions during imaging.

A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.

Magnetic particle imaging devices and methods

A Magnetic Particle Imaging (MPI) system including a mechanically-rotatable magnet generating a field-free line, where the system is capable of acquiring a plurality of projections at a plurality of rotation angles, and where the projection acquisition includes positioning the field free line at a plurality of positions at the plurality of angles.

A magnetic particle imaging apparatus includes magnets [] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scaled to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.

A magnetic particle imaging apparatus includes magnets [] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scanned to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.

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San Francisco, CA, United States of America

Patrick W Goodwill