Agency for Science, Technology and Research

Chartered Semiconductor Manufacturing Ltd (corporation)

Singapore Health Services Pte Ltd

National University of Singapore

Assistance Publique-hopitaux De Paris

Patrick Tan

Kheng Chok Tee

David Vigar

Jing Kai Tan

Bin Tean Teh

Tat Wei Chua

Lance Miller

Tatiana Ivanova

Huilin Shao

Sophie Camilleri-Broet

Xiaosai Yao

Joanna Koh

Aditi Qamra

Manjie Xing

Philippe Broet

Wen Fong Ooi

The present invention relates to a method for determining the presence or absence of at least one promoter in a cancerous biological sample relative to a non-cancerous biological sample. The present invention also relates to a method for determining the prognosis of cancer in a subject, a method for modulating the activity of at least one cancer-associated promoter in a cell, a method for modulating the immune response of a subject to cancer, a method for determining the presence of at least one cancer-associated promoter in a cancerous biological sample relative to a non-cancerous biological sample and a biomarker for detecting cancer in a subject.

Epigenomic profiling reveals the somatic promoter landscape of primary gastric adenocarcinoma

Disclosed herein is a clear cell renal cell carcinoma (ccRCC) biomarker set. Also disclosed herein is a detection system using the biomarker set disclosed herein, methods of determining whether a subject has or shows recurrence of clear cell renal cell carcinoma, method of determining whether a renal mass sample is benign or malignant, method of detecting response of a subject to systemic treatment, and a kit for carrying out the same.

Clear cell renal cell carcinoma biomarkers

The present invention relates to a pharmaceutical composition comprising an anti-cancer drug and an inhibitor of bone morphogenetic protein 4 (BMP-4) or its gene expression. The present invention also relates to methods of treating cancer and prognostic methods.

Pharmaceutical compositions for treating cancer

The invention provides an in vitro method for predicting clinical outcome of a patient affected with a non-small cell lung carcinoma (NSCLC), which method comprises determining the expression level of at least 8 genes in a biological sample of said patient.

Method for predicting clinical outcome of patients with non-small cell lung carcinoma

A new method to prevent cracking at the corners of a semiconductor die during dicing is described. Dummy metal structures are fabricated at the corners of the die to prevent cracking. The design for the dummy metal structures can be generated automatically by a computer program.

Method to make corner cross-grid structures in copper metallization

A design, device, system and process for placing slots in active regions (e.g., metal areas). Embodiments of the present invention improve the planarization of metal areas (e.g., lines) and insulators by reducing depressions (e.g., dishing) in the metal areas by including symmetric or square slots inside selected wide metal lines, by adhering to a set of placement rules. Embodiments reduce dishing in copper dual damascene structures. Embodiments reduce data processing requirements for designing and arranging the layout of IC devices and the slots.

Device, design and method for a slot in a conductive area

Growing community of inventors

Singapore, Singapore

Patrick Tan