Medtronic, Inc.

Percardia, Inc.

Alza Corporation

General Mills Chemicals, Inc.

Lifecore Biomedical, Inc.

Patrick T Cahalan

Michel L Verhoeven

Marc Hendriks

Linda L Cahalan

Benedicte Fouache

Arthur J Coury

Allan H Jevne

Edouard Koulik

Eric J Fogt

Jean A Woloszko

Kazuhiko Ishihara

Nobuo Nakabayashi

Vincent Larik

Antoine N Camps

Kenneth W Keeney

Carolann M Holmblad

Linda Lee Cahalan

Larik Vincent

Michelle A Schwinghammer

John Matthew Swoyer

Joseph B Phipps

Darrel F Untereker

Paul V Trescony

Michael J Kallok

Kenneth R Brennen

Mark W Torrianni

Marco Morra

Mirian Gillissen

Brett R Vegoe

Edward D Di Domenico

Clara Cassinelli

Judith Vincent

Benedict Fouache

Theo Lindhout

Ron Blezer

John Allen Peterson

Verhoeven Michel

Douglas Arthur Arndt

Robert W Pike, Jr

Piet Dijkstra

Eileen L Schultz

Raymond Zeeman

Jan Feijen

Benedicte Foache

Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.

Stents and methods for preparing stents from wires having hydrogel coating layers thereon

A coil is screwed into the heart wall HW between the left ventricle and coronary artery, followed by forming of a channel with laser, plasma, electrical, or mechanical device therethrough.

Corkscrew reinforced left ventricle to coronary artery channel

An implantable device for reducing restenosis includes a structure including a polyamino acid component, wherein the polyamino acid component can be in the form of a coating or a film on the structure or it can be an integral part of the structure.

Implatable device including a polyamino acid component

A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.

Methods for surface modification

A method of modifying the surface characteristics of a substrate having a surface with an amide-functional polymer thereon. The method involves contacting the amide-functional polymer with a source of hydroxide ions and a source of hypohalite ions at a temperature of at least about 20&deg; C. for a time effective to convert at least a portion of the amide-functional groups to amine-functional groups to form a substrate surface comprising an amine-functional polymer, wherein the hydroxide ions are present in a molar excess relative to the hypohalite ions and at a concentration of no more than about 0.1 M, based on the total volume of the reaction mixture. A biomolecule is attached to the resultant amine-functional polymer.

Method for attachment of biomolecules to surfaces through amine-functional groups

A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.

Implantable medical device

Method for making biocompatible medical article

Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.

Process for making a bioprosthetic device

A method of modifying the surface characteristics of a substrate, particularly a polymeric material. The method involves grafting ethylenically unsaturated monomers and attaching biomolecules, such as heparin, to the surface of the substrate, such as a polymeric material, in one step using an oxidizing metal, such as ceric ions.

One-step method for attachment of biomolecules to substrate surfaces

Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining an epoxy functionalized crosslinking agent with the collagen-based material in an aqueous medium at an acidic pH to react a portion of the collagen carboxyl groups with the epoxy functionalized crosslinking agent to form crosslinked collagen-based material comprising residual collagen carboxyl groups.

Process for making a bioprosthetic device and implants produced therefrom

A method for making a medical device having a biomolecule immobilized on a substrate surface is provided. The method includes coating the substrate surface with an amino-functional polysiloxane; and contacting the amino-functional polysiloxane coated surface with a biomolecule under conditions effective to immobilize the biomolecule.

Method for attachment of biomolecules to surfaces of medical devices

A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.

Medical device with biomolecule-coated surface graft matrix

To minimize the incidence and consequences of device related infection that occur after prosthetics implants of neuro-muscular stimulating devices, an infection resistant intra-muscular lead has been developed and is disclosed herein. Infection incidence has been decreased by using biomaterials able to release antibacterial drugs (gentamicin) at a controlled rate for the first 3-6 weeks after implant.

Intramuscular stimulation lead with enhanced infection resistance

Method of modifying the surface of a medical device

A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.

Biocompatible medical article and method

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Geleen, Netherlands

Patrick T Cahalan