Ymir Genomics, LLC

Patrick Shannon Pendergrast

Anna Irmina Markowska

Robert Scott Pendergrast

John Stephen Pendergrast

Compositions and methods for the application of non-toxic bioparticle (e.g., extracellular vesicle (EV)) absorbing materials (e.g., non-toxic exosome reducing materials) for prophylactic, therapeutic, validation and/or experimental purposes are provided.

Reduction of bioparticle levels of an organism

Compositions and methods for the isolation of protein-nucleic acid complexes and microvesicles (collectively referred to as 'bioparticles') released by mammalian cells into body fluids or cell culture media are provided. Isolated bioparticles of the invention contain biological molecules that are useful as diagnostic/prognostic biomarkers or for identification of therapeutic targets (e.g., disease or disorder-associated miRNAs). The isolation of biological molecules as described herein results in purification and concentration of the molecules. Methods for producing bio fluids that are free of detectable bioparticles, that are largely depleted of bioparticles, or that possess a reduced concentration of bioparticles compared to a bio fluid starting material (collectively termed 'bioparticle-depleted') are also provided. Isolation of bioparticle-depleted biofluid is useful, e.g., in experimental systems where it is desirable to use a biofluid that does not contain endogenous bioparticles, or has been substantially depleted of endogenous bioparticles, from the source material.

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Cambridge, MA, United States of America

Patrick Shannon Pendergrast