Centre National De La Recherche Scientifique

Agence Francaise De Securite Sanitaire Des Aliments-afssa

Biomerieux, Inc.

Universite Claude Bernard – Lyon1

Universite Claude Bernard Lyon and Biomerieux

Patrick Shahgaldian

Anthony William Coleman

Aly Moussa

Ambroise Martin

Herve Perron

Hervé Perron

Eric Da Silva

Marilyne Dupin

Edwige Leclere

Adina Nicoleta Lazar

Anna Bencsik-Reynier

A process of concentration by precipitation of PrPfor detecting or diagnosing PrP, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPfrom a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPis also disclosed.

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A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrP, the resulting suspension then being reacted with an anti-PrPantibody, and the presence of PrP is then detected.

Process for detecting PrP using a macrocyclic adjuvant ligand

Growing community of inventors

Lyons, France

Patrick Shahgaldian