Arterial Remodeling Technologies Sa

Arterial Remodelling Technologies, Inc.

Arterial Remoldeling Technologies, S.a.

Patrick Sabaria

Antoine Lafont

Michel R Vert

Tahmer Sharkawi

Serge Piranda

Serge Piranda Statice Sante

The invention is to methods of deploying polymeric biodegradable or non biodegradable stents by use of stepwise creases in the pressure placed upon the inner diameter of the stent to slowly increase the stent diameter. In one embodiment, the pressure on the interior stent diameter is slowly increased. The stent is allowed to acclimate to this diameter for a set period of time, and then the pressure is again increased. This series of steps continues until the stent reaches its final diameter and a final period of acclimatization is maintained prior to the removal of the deployment/delivery device.

Method for expansion and development of polymeric structures including stents

Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.

Polymer-based stent assembly

The present invention provides methods for fabricating a stent using a chemical treatment to smooth, polish or strengthen the stent. One such treatment involves exposing the stent to acetone or a similar solvent. In certain embodiments, the additional step comprises placing the stent in a bath containing acetone, or a similar solvent, where the bath also contains the polymer the stent is composed of. The acetone bath step may be conducted at a temperature that is below the glass transition temperature. The present invention also provides for methods of fabricating a stent using an acetone bath that comprises poly (lactic) acid. Other embodiments provide for methods of fabricating a stent using an acetone bath that comprises poly (lactic) acid and polyethylene glycol.

Methods of polymeric stent surface smoothing and resurfacing to reduce biologically active sites

Method for expansion and deployment of polymeric structures including stents

It has been determined that gamma sterilization of biodegradable polymer stents does not cause significant polymer cross-linking and collapse. Using sufficient spacing can lead to stents that display little if any detrimental effects from the procedure. In certain embodiments, using structures in the general region of about 100 micron spacing between the struts leads to highly functional stents that do not fuse. Further, the resulting stent has radially homogenous mechanical properties. Therefore, the stent has a uniform expansion within the lumen.

Method of sterilizing polymeric struts and stents

Methods of crimping polymeric stents that simultaneously apply a radial force to the stent to reduce the diameter of the stent and a longitudinal force to elongate of the stent. According to one such method, a stent is inserted into an elastic tube having an inner surface that defines a passage. The tube is pulled to cause stretching of the tube. When the tube is stretched, the inner surface of the tube engages an outer surface of the stent and applies simultaneous longitudinal and radial forces to the outer surface of the stent. The simultaneously applied longitudinal and radial forces simultaneously reduce a radial extent of the stent and increase a longitudinal extent of the stent.

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Saint Nom la Breteche, France

Patrick Sabaria