University of Washington

Phaserx, Inc.

University of Massachusetts

Genevant Sciences Gmbh

Other

Patrick S Stayton

Allan Sachs Hoffman

Paul Hickok Johnson

Anthony Convertine

Robert W Overell

Anna S Gall

Craig L Duvall

Charbel Diab

Priyadarsi De

Mary Gallagher Prieve

Danielle Benoit

Niren Murthy

Pierre D Mourad

Amber E E Paschal

Lawrence A Crum

David A Tirrell

Oliver Press

Tyrone M Porter

Anthony J Convertine

Paul Johnson

Selvi Srinivasan

Chantal Lackey Reed

Jriuan Lai

Richard Glen Ellenbogen

Sean D Monahan

Michael S DeClue

Forrest M Kievit

Donghoon Lee

Joshua Sang Hun Park

Barrett J Nehilla

Julia Mengyun Xu

Jr-iuan Lai

John Hoffman

Mitsuhiro Ebara

Scott M Henry

Menko P Ypma

Peter A Chiarelli

David Baker

Tsuyoshi Shimoboji

Daniel M Ratner

Kjell E Nelson

Amber E Paschal

Noah Malmstadt

Yifan Song

Amber Ee Paschal

Michael Nash

Xiangchun Yin

Lakeshia J Taite

Jessica Garbern

Samarth Kulkarni

Brian Albarran

Richard To

Chantal Lackey

Erik Procko

Todd C McDevitt

Geoffrey Y Berguig

Stephanie Ann Berger

Daniel-Adriano Silva

Debobrato Das

Robert Overell

Paul H Johnson

Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Oxygen reactive polymers for treatment of traumatic brain injury

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Micellic assemblies

Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock copolymers, polymeric architectures that include the copolymers and diblock copolymers, and particles assemblies comprising the copolymers, diblock copolymers, and polymeric architectures that include the copolymers.

Stabilized polymeric carriers for therapeutic agent delivery

Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective &#x3c9;-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.

&#x3c9;-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.

Diblock copolymers and polynucleotide complexes thereof for delivery into cells

The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and are thus useful for treating Epstein Barr-related diseases and cancer.

Polypeptides to inhibit epstein barr viral protein BHRF1 and B cell lymphoma family proteins

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution.

Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates

Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.

Targeting monomers and polymers having targeting blocks

Growing community of inventors

Seattle, WA, United States of America

Patrick S Stayton