Alza Corporation

Durect Corporation

Encinal Pharmaceutical Investments, LLC

Patrick S L Wong

Liang-Chang Dong

Atul D Ayer

Steven Espinal

David E Edgren

Anthony L Kuczynski

Gurdish K Bhatti

Vincent Joseph Ferrari

Liang C Dong

Padmaja Shivanand

Zahedeh Hatamkhani

Felix T Theeuwes

Judy A Magruder

George V Guittard

Andrew C Lam

Jerry D Childers

Michael A DesJardin

Lawrence G Hamel

Shu W Li

Robert R Skluzacek

Shaoling Li

Glen E Barclay

Stephen S Hwang

Jiansheng Wan

The invention disclosed comprises a method for administering the antidiabetic drug glipizide to a patient in need of glipizide in need of antidiabetic therapy.

Method for lowering blood glucose

The invention pertains to a dosage formand to administering an antidepressant medicamentfor an extended period of time in a rate-known dose.

Antidepressant dosage form

A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200&#xb0; C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.

Dosage form comprising liquid formulation

The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.

Expandable osmotic composition and coating suspension

Improvements in a mini-osmotic pump and coating compositions are described. The dispensing pump includes an inner fluid-filled bag encased by an osmotic layer and outer, semi-permeable membrane. The inner bag is formed with an arcuate edge at the open end of the bag to inhibit formation of fissures in the outer membrane in this edge region. The coating compositions include cellulose acetate butyrate, cellulose acetate propionate, and polymethylmethacrylate polymers, optionally mixed with ethyl cellulose in acetone based solvent systems.

Osmotically-driven fluid dispenser

A dosage form is disclosed comprising a drug formulation that self-emulsifies in the drug formulation.

A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.

Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings

The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.

Mixing system for an active agent delivery device

A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of time up to 24 hours.

Dosage form comprising therapeutic formulation

The invention disclosed pertains to a novel delivery system comprising an agent formulation and means for dispensing the agent formulation from the delivery system.

Uniform drug delivery therapy

A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.

Hydrocodone therapy

A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.

Osmotic dosage form composed of an extruded polymer tube form

The invention pertains to a dosage form and to administering an antidepressant medicament for an extended period of time in a rate-known dose.

Method of administering antidepressant dosage form

A dosage form comprising a composition comprising a drug surrounded by an interior and an exterior wall with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.

Growing community of inventors

Burlingame, CA, United States of America

Patrick S L Wong