Tarveda Therapeutics, Inc.

Tva (abc), LLC

Patrick Rosaire Bazinet

Mark T Bilodeau

Sudhakar Kadiyala

Rajesh R Shinde

Richard Wooster

Beata Sweryda-Krawiec

Rossitza Gueorguieva Alargova

Brian H White

Craig Antony Dunbar

Patrick Lim Soo

Kerry Whalen

Samantha Perino

Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Targeted conjugates and particles and formulations thereof

Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

SSTR-targeted conjugates and particles and formulations thereof

Growing community of inventors

Somerville, MA, United States of America

Patrick Rosaire Bazinet