Dartmouth College

William Marsh Rice University

Patrick R Cushing

Dean R Madden

Lars Vouilleme

Rudolf Volkmer

Prisca Boisguérin

Brian Vincent Popp

Zachary Thomas Ball

Prisca Boinguérin

Rituparna Kundu

Prisca Boisguearin

Rudolph Volkmer

A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic, anti-inflammatory agent or a combination thereof are provided as is a method for preventing or treating cystic fibrosis.

Therapy and kit for the prevention and treatment of cystic fibrosis

Combination therapy and kit for the prevention and treatment of cystic fibrosis

Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein.

Small molecule conjugates with dimetal species for protein inhibition

The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.

Compositions and methods for inhibiting the interaction between CFTR and CAL

Growing community of inventors

Woburn, MA, United States of America

Patrick R Cushing