Celltech R&d Limited

Ucb S.a.

Patrick R Charmley

Kai Hua Wang

Rhodora H Argonza-Barrett

Mark D McEuen

Matthew P Fitzgibbon

Ryan C Smith

Patrick D Moss

Mary E Brunkow

Bryan W Paeper

Sean Proll

Andreas Gerardus Uitterlinden

The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis.

19.5 polypeptide antibodies useful for diagnosing or treating psoriasis

Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.

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In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.

Compositions and methods for diagnosing or treating psoriasis

Antibodies for diagnosing psoriasis

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Seattle, WA, United States of America

Patrick R Charmley