Commissariat a L'energie Atomique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Biomerieux Sa

Avalun

Centre National De La Recherche Scientifique

Biomerieux, Inc.

Universite Claude Bernard – Lyon1

Université Joseph Fourier

Cnrs

Institut National Des Sciences Appliquees De Lyon

Ecole Centrale De Lyon

Cpe Lyon Formation Continue Et Recherche

Biom Rieux S.a.

Patrick Pouteau

Vincent Poher

Pierre Labeye

Myriam-Laure Cubizolles

Cédric Allier

Magalie Faivre

Johanna Spiaczka

Cyril Delattre

Jean Berthier

Gilles Grand

Raymond Charles

Jean-Guillaume Coutard

Philippe Peltie

Raymond Campagnolo

Frederic Ginot

Frédéric Ginot

Anne Planat-Chretien

Patrice Caillat

Pierre Gidon

Cedric Allier

Mathieu Dupoy

Jean-luc Achard

Claude Chabrol

Patrick Chaton

Christian Jeandey

Hervé Rostaing

Gilles Marchand

Maryse Fournier

Vincent Delisle

Pierre Puget

Skandar Basrour

Frédéric Mallard

Myriam Laure Cubizolles

Jacques Margail

François Perraut

Christine Peponnet

Cécile Bory

Isabelle Chartier

Cécile Jamois

Jean Luc Achard

Elodie Sollier

Marie-Line Cosnier

Maxime Huet

Daniel Bec

Stephane Le Brun

Lotfi Berguiga

Herve Denis

Jean-Marc Fedeli

Nicolas Gaignebet

Taha Benyattou

Arnaud Buhot

Marjolaine Allain

Valerie Lapras

Paul Laurens

Caroline Fontelaye

Amélie Bellemin Comte

Gwenola Sabatte

Magali Faivre

Anne Planat Chretien

Stéphane Le Brun

A method for analysing a sample uses a resonant support having a surface on which a plurality of separated photonic crystals extends. At least two crystals are configured to capture the same analyte. A resonance wavelength associated with each crystal varies with an amount of analyte in contact with the crystal. The wavelengths define a resonance spectral band between 200-1500 nm. The transmission/reflection of the light is maximum at an associated resonance wavelength. The method includes: illuminating the support in the resonance spectral band, the intensity of the lamination being variable in band; acquiring a measurement image using an image sensor, the image having different regions-of-interest each optically coupled to a photonic crystal; using a reference image representative of an image acquired by the image sensor, when the support is illuminated in the resonance spectral band in a reference configuration; and comparing the measurement image with the reference image.

Method and device for analysing a sample, implementing a resonant support

A device for collecting a liquid sample by capillarity includes distinct first and second elements having respective male and female parts. The male part comprises a channel having a transverse section. The female part comprises a peripheral wall that transversely delimits a cavity to house the male part. A part of the peripheral wall forms a cap to close the transverse section when the female part houses the male part.

Device for collecting a liquid sample by capillarity

A device for taking a sample of liquid by capillarity, including a channel for flow of the liquid delimited by two internal walls of the device between which a channel bottom extends, the distance separating the two internal walls decreasing in the direction of the channel bottom, the channel extending between a first collecting end, open onto outside of the device and configured to receive the liquid, and a second end, to enable the liquid to flow by capillarity along the channel bottom from the first end towards the second end. The channel includes, at the second end, a blocking structure to block the flow of liquid in the channel from the first end towards the second end.

Device for taking a liquid sample by capillarity and associated analysis method

The invention relates to a system for analyzing a liquid sample, including an analysis device comprising a casing including a through-opening leading into a housing adapted to receive a portion of a collecting device and extending longitudinally from the opening along an axis of insertion of the collecting device. The analysis system further includes a collecting device comprising a main body extending along a longitudinal axis and including a fluid chamber adapted to be inserted in the housing along the insertion axis and a receiving surface intended to receive the liquid sample extending substantially orthogonally relative to the axis of the main body.

System for analyzing a liquid sample

The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood.

Method for estimating an amount of analyte in a fluid

The method is provided for characterizing agglomeration of particles in a liquid containing an analyte, including introducing liquid into a fluid chamber; mixing the liquid with a bifunctional reagent, lighting the fluid chamber using an excitation light beam extending through the fluid chamber in a longitudinal direction (X); acquiring at least one image using a matrix photodetector, each image including pixels (I(x,y), x,y representing the coordinates of a pixel of an image, the image (I(x,y)) being formed by radiation transmitted by the lighted fluid chamber; and calculating from at least one acquired image (I(x,y)), at least one indicator (Ind) characterizing the particle agglomeration. The photodetector can be positioned less than 1 cm from the fluid chamber, and during the calculation step, the calculated indicator (Ind) is representative of the intensity of the pixels of the image. The method advantageously allows for characterizing the agglomeration of particles in a liquid.

Method and system for characterizing the agglomeration or speed of particles contained in a liquid, such as blood particles

This method for estimating the quantity of an analyte contained in a liquid includes the following steps:

Method and system for estimating the quantity of an analyte contained in a liquid

A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma is provided. The method includes illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images. The processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.

Device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma

A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma, the method including: illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images; wherein the processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.

Method and a device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma

A device for interconnecting a card including at least one first fluid channel, emerging from a connection side parallel to a support side, the interconnection device including: a first surface configured to receive the support side of the card; a second surface parallel to the first surface, from which a second fluid channel emerges; and a mechanism to hold the card in place, configured to hold a connection side of the card pressed against the second surface of the device, such that first fluid channel is in fluid connection with the second fluid channel.

Microfluidic card connection device

The method according to the invention is capable of characterizing a variation in the speed of particles or agglomeration of particles, the particles, such as blood particles, being contained in a liquid (). The characterization method includes the following steps: During the acquisition step, the photodetector () is positioned at a distance (D) smaller than 1 cm from the fluid chamber () in the longitudinal direction (X).

Method and system for characterizing the movement speed of particles contained in a liquid, such as blood particles

A microfluidic valve including a microchannel, a membrane arranged so as to seal off the microchannel and equipped with resistive units, characterized in that at least one face of the membrane includes at least one groove, and in that the resistive units are arranged in the groove and are capable, when an electric control current flows through them, of expanding sufficiently under the effect of the heat produced by the flow of the electric current to cause the rupture of at least one part of the membrane.

Single use microfluidic valve

Disclosed herein is a device for sampling blood by capillarity for separating a plasma phase of the blood from the cell phase. The device is a strip and includes a filter having a membrane with no clumping agents, a prefilter for spreading blood over the surface of the membrane; and an absorbent paper downstream from the filter. The membrane is dimensioned to cover only a part of the surface of the prefilter and the migration of blood by capillarity within the prefilter takes place essentially lengthwise relative to the strip before blood comes into contact with the membrane.

Blood sampling device comprising at least one filter

A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.

Method and device for division of a biological sample by magnetic effect

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Meylan, France

Patrick Pouteau