Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Sorbonne Université

Université De Technologie De Compiègne

Université Technologie De Compiègne-utc

Patrick Paullier

Olivier Scatton

Eric Savier

Eric Leclerc

Cécile Legallais

Régis Baudoin

Jean-Matthieu Prot

Franck Merlier

Cecile Legallais

Regis Baudoin

Aissa Ould Dris

Aïssa Ould Dris

Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The 'arterial' outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.

Organ perfusion device

Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The 'arterial' outlet of the first path has a diameter smaller than a diameter of the 'portal' outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the &#x201c;arterial&#x201d; outlet of the first path more than the fluid emerging from the &#x201c;portal&#x201d; outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.

The present invention relates to a unit () comprising a microsystem () and at least one set of interface connections () for the microsystem (); the microsystem () comprising a bottom plate () bearing the impression of at least one microstructured dynamic cell culture chamber (), and a top plate (), characterized in that the at least one microstructured chamber () is fluidically connected at inlet and/or at outlet by a set of connections () inserted removably into a hole in the upper plate (). The present invention also relates to a dynamic cell culture system to this effect.

Multi-reactor unit for dynamic cell culture

The invention concerns a facility for coupling a bioreactor for culturing bio-organisms, in dynamic mode, with at least one device for physicochemically analyzing a fluid from this bioreactor or collecting samples of this fluid, the device being equipped with a pump and an injector, the bioreactor being equipped with means for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor is connected to a closed perfusion loop provided with a pump, fitted with a sampling loop and in that the facility comprises:

Facility for coupling a bioreactor with a device for physicochemically analysing or collecting samples

Growing community of inventors

Thourotte, France

Patrick Paullier