Ambit Biosciences Corporation

Discoverx Corporation

Patrick Parvis Zarrinkar

David J Lockhart

Daniel Kelly Treiber

Pietro Ciceri

Hitesh K Patel

Zdravko V Milanov

Shamal Anil Mehta

William H Biggs, Iii

Miles A Fabian

The invention provides methods for determining the interactions between phage-displayed proteins and test molecules. The phage-displayed proteins are contacted with a reference moiety in the presence and absence of a test molecule; the behavior of the phage-displayed proteins as a function of concentration of the test molecule permits calculation of the binding affinity of the phage-displayed protein for the test molecule.

Assays and kits for detecting protein binding

The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage propagation, in the absence of display of heterologous polypeptides, which may be expressed as a fusion with said coat protein in a regulated manner.

Uncoupling of DNA insert propagation and expression of protein for phage display

The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treatment of neurodegenerative diseases, cardiovascular diseases, proliferative diseases, and visual disorders. In particular, methods and compositions for the treatment of stroke are disclosed herein.

Pyrrole compounds and uses thereof

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San Diego, CA, United States of America

Patrick Parvis Zarrinkar