Ab Sciex LLC

Eksigent Technologies, LLC

Patrick Pak-Ho Leung

Don Wesley Arnold

Jason E Rehm

Kenneth R Hencken

Douglas Robert Cyr

Sammy S Datwani

Phillip Harris Paul

David J Rakestraw

A junction is made between a first microfluidic substrate () having an elongate component () protruding from it and a second microfluidic substrate () having a corresponding conduit (). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces () or grooves () in opposite sides of the substrate. The substrates are placed on an alignment jighaving location features () corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.

Microfluidic connections

Particles dispersed in a liquid are assembled in a configuration in which all the particles lie in the same plane, and the assembled particles are processed while in that configuration. The assembled particles can for example be simultaneously exposed to electromagnetic radiation which elicits from the particles a response which provides information about the particles. The particles can for example be cells, cell fragments, or analyte-bearing beads of the type conventionally analyzed in a cytometer.

Processing of particles

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Belmont, CA, United States of America

Patrick Pak-Ho Leung