Other

Thomas Jefferson University

Patrick Most

Walter J Koch

Joseph E Rabinowitz

Hugo A Katus

Andrew Remppis

Sven T Pleger

The invention provides nucleic acid segments, compositions and methods for the treatment of heart failure, vascular dysfunction, endothelial dysfunction, diabetes, [Ca]i regulation and NO synthase dysfunction. Adeno-associated and adenovirus are used as gene delivery vectors for the nucleic acid segments to product long term over-expression of S100A1, a small calcium sensing protein associated with the disclosed ailments and dysfunctions.

Tissue specific gene therapy treatment

The invention relates to medicaments for treating cardiac power failure. The medicaments contain a therapeutically effective quantity of one or more S100 protein(s) or one or more mutant or fragments of the same, or contain one or more nucleic acid sequence(s) which code(s) for these amino acid sequences and which are optionally integrated in one or more gene transfer vectors.

Treatment of cardiac power failure

Growing community of inventors

Philadelphia, PA, United States of America

Patrick Most