Array Biopharma Inc.

University of Colorado

Patrick Michael Barbour

Adam Wade Cook

Ellen Ruth Laird

Qian Zhao

Shelley Allen

Li Ren

David A Moreno

John Joseph Gaudino

Ronald Jay Hinklin

Andrew T Metcalf

Erik James Hicken

Oren T McNulty

Bradley Jon Newhouse

Spencer Phillip Pajk

Dean Russell Kahn

Joshua Ryan Dahlke

Brett Joseph Prigaro

Eugene Tarlton

Katie Keaton Brown

Xiang Wang

Oren Teague Mcnulty

Andrew Terrance Metcalf

Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R, R, R, Xand G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases

Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X, R, R, R, R, Rand Rare as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Compounds for the treatment of BRAF-associated diseases and disorders

Provided herein are compounds of the Formula I: and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R, R, R, Xand G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are capable of re-sensitizing the susceptibility of methicillin-resistantto a &#x3b2;-lactam antibiotic. The present invention also relates to a method for producing and using the same.

Polycyclic indoline and indolenine compounds

Growing community of inventors

Westminster, CO, United States of America

Patrick Michael Barbour