Oklahoma Medical Research Foundation

Other

The University of Oklahoma

Patrick M Gaffney

Lijun Xia

Kathy L Moser

Jianxin Fu

Klaas Wierenga

Yuji Kondo

Hua Wang

The present invention includes a method of treating a bone disease caused by a intracellular protein trafficking defect comprising: identifying a subject having the bone disease caused by the intracellular protein trafficking defect in a membrane bound transcription factor peptidase, site 1 (MBTPS1) gene; and providing the subject with an effective amount of a composition that bypasses or corrects a defect in MBTPS1 gene expression, gene splicing, or corrects protein trafficking defects in the endoplasmic reticulum and to the lysosome.

Treatment for skeletal diseases caused by intracellular protein trafficking defects

The present invention provides methods for the prediction and diagnosis of autoimmune diseases, including Systemic Lupus Erythematosus, using single nucleotide polymorphism in TNFAIP3 (A20).

Predicting and diagnosing patients with autoimmune disease

A one-handed knife system in which a knife having a blade instantly deployed by pulling on the heel section thereof includes a separable tether which separates under a force greater than the force required to deploy the blade.

One-handed knife system

Growing community of inventors

Oklahoma City, OK, United States of America

Patrick M Gaffney