Tarveda Therapeutics, Inc.

Placon Therapeutics, Inc.

Tva (abc), LLC

Patrick Lim Soo

Rossitza Gueorguieva Alargova

Mark T Bilodeau

Rajesh R Shinde

Craig Antony Dunbar

Richard Wooster

Beata Sweryda-Krawiec

Sudhakar Kadiyala

Brian H White

Patrick Rosaire Bazinet

Benoît Moreau

Edward R Lee

Timothy E Barder

Danielle N Rockwood

J Michael Ramstack

Kerry Whalen

Leila Alland

Christopher Sears

Sukhjeet Singh

Tsun P Au Yeung

Linda M Custer

Danille N Rockwood

Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Targeted conjugates and particles and formulations thereof

Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

SSTR-targeted conjugates and particles and formulations thereof

The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.

Platinum compounds, compositions, and uses thereof

The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.

Compounds, compositions, and methods for the treatment of cancers

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Ridgewood, NJ, United States of America

Patrick Lim Soo