Rhone-poulenc Rorer S.a.

Merial Limited

Aventis Pharmaceuticals Products Inc.

Aventis Pharmaceuticals Inc.

Rhone-poulenc Rorer Pharmaceuticals Inc.

Rhone Poulenc Rorer

Patrick Leon

Denis Largeau

Gilles Oddon

Denis Pauze

Michael K O'Brien

Thierry Durand

Michael O'Brien

Matthew Powers

Matthew R Powers

Luc Grondard

Benoit J Vanasse

Frederic Lhermitte

Ronan Guevel

Herve Garcia

Laurent Garel

Eric Didier

Adam W Sledeski

Ching T Tsuei

Tory H Powner

Fr&eacute;d&eacute;ric Lhermitte

Daniel Robin

Ching Tsuei

Jean-Paul Casimir

Dominique Petre

Viviane Massonneau

Roland Jacquot

Xavier Radisson

Michel Lavigne

James J Mencel

Didier Bernard

Christophe Daubie

Laurence W Reilly

Robert C Liu

Gregory G Kubiak

Robert Stammler

Philippe Pitchen

Francis L Walther

Michael D Thompson

Harshavadan C Shah

Fran&ccedil;ois Basset

Jildaz Dhainaut

Didier Riguet

Laurence Pailleres-Hubert

Benoit Viguier

Geoffrey A D'Netto

The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula Iby stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4&#x2033; position in a corresponding derivative of formula II.

Process of use in converting the 4&#x2033;(S)-OH functional group of the cladinose unit of an azamacrolide to 4&#x2033;(R)-NH2

Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A

Process which is useful for converting the carbonyl function in position 4&Prime; of the cladinose unit of an aza-macrolide into an amine derivative

Process for the preparation of 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A derivatives from 9-deoxo-9 (Z)-hydroxyiminoerythromycin A

This invention is directed to methods for stereospecifically preparing &lsqb;(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)&rsqb;-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.

Steroespecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines

This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

Process for preparing N6-substituted adenosine derivatives

Process of use in converting the 4&Prime;(S)-OH functional group of the cladinose unit of an azamacrolide to 4&Prime;(R)-NH2

This invention is directed to methods for the preparation of &lsqb;1S-&lsqb;1a,2b,3b,4a(S*)&rsqb;&rsqb;-4-&lsqb;7-&lsqb;&lsqb;-(3-chloro-2-thienyl)methyl&rsqb;propyl&rsqb;amino&rsqb;-3 H-imidazo&lsqb;4,5-b&rsqb;pyridin-3-yl&rsqb;&rsqb;-N-ethyl-2,3-dihydroxycyclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.

Preparation of is-&lsqb;1A,2B,3B,4A(S*)&rsqb;-4-&lsqb;7-&lsqb;&lsqb;1-(3-chloro-2-Thienyl)methyl&rsqb;amino&rsqb;-3H-imidazo &lsqb;4,5-B&rsqb;pyridin-3-YL&rsqb;-N-ethyl-2,3-dihydroxycyclopentanecarboxamide

This invention is directed to a process for preparing a pseudotetrapeptide of formula I

Process for the preparation of azacycloalkylakanoyl pseudotetrapeptides

This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxyc yclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.

Preparation of

This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.

Stereospecific preparation of chiral 1-aryl-and

The present invention relates to a novel process for preparing dialkoxy derivatives of the taxoid family by direct alkylation of the two positions 7 and 10 of deacetylbaccatin or derivatives thereof which are esterified in position 13.

Process for preparing derivatives of the taxoid family

Novel derivatives of 1R- or 1S-2-azabicyclo�2.2.1!heptane with the general formula (I) or (I'), preparation and their application. ##STR1## In the general formulas (I) and (I'), R represents a hydrogen atom or a group with the formula ##STR2## respectively, in which R.sub.1 represents an alkyl group containing 1-4 carbon atoms and Ar represents an optionally substituted phenyl or a- or b-naphthyl group.

Derivatives of 2-azabicyclo�2.2.1! heptane, their preparation and their

A method for the preparation of a lactam compound of formula ##STR1## wherein R'.sub.1 and R'.sub.1 independently are acyl or aroyl, or taken together form an optionally substituted methylene, and G.sub.1 is hydrogen or an amino protecting group, comprising oxidizing a bis O-protected 1R-2-azadihydroxybicyclo-�2.2.1!heptane compound of formula ##STR2## with about 0.1 mol % to about 1 mol % of RuO.sub.2 or hydrate thereof in the presence of about 3 equivalents of an oxidant to form the lactam compound with an enantiomeric excess of greater than or equal to about 95%.

L-tartaric acid salt of a (1R) diastereomer of a

A method for the preparation of a compound of formula ##STR1## wherein R is hydrogen or, respectively, a group of formula ##STR2## R.sub.1 is alkyl; Ar is optionally substituted aryl; and

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Tassin la Demi Lune, France

Patrick Leon