Rhone-Poulenc Rorer S.a.

Aventis Pharma S.a.

Patrick Lefevre

Pascal Anger

Bertrand Bonnavaud

Jean-Claude Barriere

Alain Callet

Jean-Marc Paris

Denis Thibaut

Luc Grondard

Stephane Mutti

Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R is Me or Et, R is H or OH, and R is substituted benzyl of general formula (III), such that 1) if R is H, R is NR R , wherein one of R and R is H or an Me radical and the other is Me, and R&prime; is Cl or Br, or R is (C3-5)alkenyl if R and R are Me, or 2) R is H and R&prime; is halogen, alkylamino or dialkylamino, an ether-oxide residue, alkylthio, (C1-3)alkyl or trihalogenomethyl, or R is halogen, (C2-4)alkylamino, (C2-4)dialkylamino or methyl ethyl amino, pyrrolidino alkenyl alkyl amino, dialkylamino, an alkyl cycloalkylmethyl amino radical or in ether-oxide residue, alkylthio, alkylthiomethyl, (C1-6)alkyl, aryl or trihalogenomethyl, and R&prime; is H, or R is halogen, amino, alkylamino or dialkylamino, an ether-oxide residue, an alkylthio radical, (C1-6)alkyl or trihalogenomethyl and R&prime; is halogen, alkylamino or dialkylamino, an ether-oxide residue or alkylthio, (C1-3)alkyl, cocrystallised with one or more minor components of group A of general formula (II) wherein R&Prime; is H, Me or Et.

Purified form of streptogramines, preparation of same and pharmaceutical compositions containing them

Method for preparing streptogramins

This invention relates to a purified form of streptogramins, having of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical,

Purified form of streptogramins, its preparation and pharmaceutical

This invention relates to a purified form of streptogramins, consisting of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent --CH.sub.3, and R.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R' is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.

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Vincennes, France

Patrick Lefevre