Synthes Usa, LLC

Lifecell Corporation

Synthes Gmbh

Patrick Leamy

Sean Hamilton Kerr

Mark T Fulmer

Ira C Ison

Michael Lehmicke

Bryan Monro Armitage

William Schiffer

Yi Heng Chen

Hui Xu

Wenquan Sun

Kai-Roy Wang

Hua Wan

Li Ting Huang

Nimesh Kabaria

Mrinal Shah

Israel Jessop

Ira Ison

Yi Chen

Brian Monroe Armitage

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.

Method for enzymatic treatment of tissue products

The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Bone cement compositions having fiber-reinforcement and/or increased flowability

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Downingtown, PA, United States of America

Patrick Leamy