Hewlett-packard Company

Agilent Technologies, Inc.

Other

Caliper Technologies Corporation

Caliper Life Sciences, Inc.

Patrick Kaltenbach

Sally A Swedberg

Laurie S Mittelstadt

Klaus E Witt

Fritz Bek

Colin B Kennedy

Manfred Berndt

Morten Juel Jensen

Tom A Van De Goor

Volker Brombacher

Stefan Falk-Jordan

Garrett Unno

Gordon Ross

A fluidic device () comprising a substrate () and a transport medium () provided on the substrate () to define a transport path for transporting a fluidic sample () driven by an electric force.

Channelless fluidic sample transport medium

In a system for operation or handling of a laboratory microchip () for chemical processing or analysis, the microchip () is mounted in a first physical unit (). The microchip () is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit () comprises an optical device () for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.

Apparatus for the operation of a microfluidic device

In a system for operation or handling of a laboratory microchip ( ) for chemical processing or analysis, the microchip ( ) is mounted in a first physical unit ( ). The microchip ( ) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit ( ) comprises an optical device ( ) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.

A modular microchannel apparatus for analysis of an analyte. The apparatus includes a separation unit and a reservoir unit. The separation unit has a microchannel. The analyte can be driven to pass through the microchannel such that the time for the analyte to pass through the microchannel is indicative of the molecular characteristics of the analyte. The reservoir unit has one or more reservoirs for coupling operatively modularly with the separation unit to supply liquid reagents to the separation unit. The reservoirs has prepackaged liquid reagents in it before the reservoir unit is coupled with the separation unit.

Modular apparatus for chemical microanalysis

Systems and methods for analyzing a sample are disclosed. The system may include a light source operable to transmit light onto the sample, a detector operable to detect intensity of the light emitted from the sample, and a power modulator. The power modulator modulates the light source power such that light is emitted from the light source in more than one mode to reduce changes in the emitted light due to temperature changes in the light source.

Light source power modulation for use with chemical and biochemical analysis

Microfluidic devices and systems that include keying, registration or indication elements that communicate a functionality of the microfluidic device to the instrumentation which is used in conjunction with these devices. Indicator elements include structural indicators, electrical indicators, optical indicators and chemical indicators. Different indicator elements are indicative of different functionalities, e.g., applications, new vs. used, and the like.

Indicator components for microfluidic systems

A miniaturized ion analysis system with a contactless conductivity detection means is described for use in liquid phase sample analysis and detection. The device is formed by microfabrication of microstructures in novel support substrates. The detection means can be fabricated directly in the support body at the point of detection or other locations on the device or, alternatively, may be formed as part of a modular structure that is insertable into the device at the point of detection. In addition, a method is provided for analyzing ionic species present in a sample using the miniaturized ion analysis device. The invention herein is used for the analysis of ionic solutes in the liquid phase.

Miniaturized device for ion analysis, and methods of use thereof

Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the methods of the invention include associated laser-ablated features required for function, such as on-device reservoirs or makeup flow compartments, analyte detection means and sample injection means. The miniaturized columns can be used in an apparatus intended for analysis of either small and/or macromolecular solutes in the liquid phase which employs chromatographic, electrophoretic or electrochromatographic separation means. The apparatus can include a variety of optional injection means, manifolds, keeper means, post column collection means, and combinations thereof.

Miniaturized planar columns for use in a liquid phase separation apparatus

A chip for performing an electrophoretic separation of micromolecular or macromolecular structures in two dimensions comprises a base substrate comprising a main surface. A channel is formed in the main surface of said base substrate in a first direction, wherein a first voltage is applicable across the channel in order to allow a separation of micromolecular structures or macromolecular structures in the first direction on the basis of a first separation mechanism. In addition, a two-dimensional separation matrix is formed in the main surface of the base substrate, wherein the separation matrix comprises a shallow recess and an array of stand-alone posts arranged in the recess. The recess extends perpendicular from the channel in a second direction, wherein a second voltage is applicable across the separation matrix in order to allow a separation of the structures on the basis of a second separation mechanism.

Chip for performing an electrophoretic separation of molecules and method using same

Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.

Miniaturized planar columns in novel support media for liquid phase

Miniaturized planar columns for use in a liquid phase separation

A photometric apparatus (100) for small sample volumes comprises a cell body (102), a light input means (104) arranged adjacent to a first surface of the cell body (102), a light source (105) emitting light of predetermined wavelength or wavelength range through the light input means (104), a light output means (106) arranged adjacent to a second surface of the cell body (102) opposite to the first surface, a light detector (107) arranged adjacent to the light out put means (104), and a flow channel (108) formed in the cell body (102), wherein surfaces of the walls of the channel (108) have a roughness smaller than the predetermined wavelength.

Growing community of inventors

Bischweier, Germany

Patrick Kaltenbach