Tampa Bay Research Institute

Patrick K Lai

Akiko Tanaka

Meihan Nonoyama

Kunio Konno

Hiroshi Sakagami

Yutaka Kawazoe

A protein having potent anti-HIV activity is obtained by a method which comprises culturing a strain of CD4-positive T cells, such as a subclone of CEM cells designated 4084, in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity is at least 30,000 daltons as determined by a membrane with defined pore size that retains molecules of 30,000 daltons.

Protein having anti-HIV activity and method for obtaining it

A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity, as measured by gel filtration analysis, is within the range of about 7,000 to about 12,000 daltons.

Process for obtaining cellular protein having anti-HIV activity

Polymers of p-hydroxylated cinnamic acids and p-hydroxylated cinnamyl alcohols have potent anti-viral activity in vitro.

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Clearwater, FL, United States of America

Patrick K Lai