Systagenix Wound Management (us), Inc.

Ethicon, Gmbh

The University of Akron

Kci Usa, Inc.

Woundchek Laboratories (us), Inc.

Woundcheck Laboratories (us), Inc.

Systagenix Wound Management, Limited

Systagenix Wound Management IP Co B.v.

Patrick John Trotter

Breda Mary Cullen

Paul W Watt

Rachael Louise Clark

Faraia Shah

Daniel J Smith

Frank Richard Cichocki, Jr

Frank Cichocki

Sara Jayne Gregory

Mahesh Bhide

Donald Christopher Marsden

Derek Walter Silcock

Paul William Watt

The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.

Debridement method using topical nitric oxide donor devices and compositions

The present invention relates to monitoring patients for an inflammatory condition or infection (preferably wound infection) by testing an extracellular fluid such as a wound fluid for an elevated level of: (i) vimentin; (ii) a vimentin breakdown product; or (iii) a marker indicative of the presence of vimentin. The present invention provides methods of diagnosis and prognosis, wound dressings, devices (e.g. biosensors) and kits for use in such methods.

Measurement of cytoskeletal proteins and uses thereof in diagnosis, prognosis and therapy

A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.

Methods for the treatment of wounds

The present invention relates to the diagnosis, prognosis and/or treatment of wound infection by testing wound fluid for the presence of a marker which is present in an amount which is indicative of infection. The marker may be high molecular weight phospholipase A(cPLA) or a marker which is correlated with cPLA.

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Disclosed is a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages, wherein the cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.

Pain-sensitive therapeutic wound dressing

The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.

Pain-sensitive therapeutic wound dressings

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Leeds, United Kingdom

Patrick John Trotter