Sterling IP Limited

Nascient Limited

Patrick John Hextall

Kim Suzanne Midwood

Philip Bland-Ward

Nigel Burns

Susan Rebecca Aungier

Eric Culbert

Philip Antony Bland-Ward

There is provided antibodies or antigen-binding fragments, derivatives or variants thereof which are capable of binding to the FBG domain of tenascin-C. There are also provided uses of such antibodies or antigen-binding fragments, derivatives or variants thereof, as well as methods of identifying such antibodies.

Anti-tenascin C antibodies and uses thereof

The present disclosure relates to antibodies and binding fragments to a Tenascin, in particular the FBG domain of a Tenascin, which are potentially less immunogenic than the parent antibody. The disclosure also relates to compositions comprising the antibody or binding fragment and use of any one of the same for diagnosis, prognosis and/or treatment of disorders such as those associated with chronic inflammation. The disclosure further provides methods of making the antibodies.

Human antibodies and binding fragments thereof to tenascin

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Cambridge, United Kingdom

Patrick John Hextall