Merck + Co., Inc.

Patrick J Cassidy

Sebastian Hernandez

Robert T Goegelman

Sheldon B Zimmerman

Edward O Stapley

Satoshi Omura

Ruiko Oiwa

James E Flor

Ray S Dewey

Josefino B Tunac

Jean S Kahan

There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.

Process for producing A73A, a new Efrotomycin-like antibiotic in

The antibiotic MSD 890A.sub.10 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.10) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.

Antibiotic 890A.sub.10

The antibiotic MSD 890A.sub.9 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.9) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.

Method of producing antibiotic 890A.sub.9

Discovery of A73A, a new efrotomycin-like antibiotic in fermentation

The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.

Process for producing antibiotics by cultivation of Streptomyces

Disclosed is a process for enzymatically cleaving the acyl group from N-acyl-6-substituted-2-substituted-1-carbadethiapen-2-em-3-carboxylic acids. The acylated substrate and the deacylated product are antibiotics.

Process for deacylating

The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.

Growing community of inventors

Rahway, NJ, United States of America

Patrick J Cassidy