Eli Lilly and Company

Dowelanco

Patrick J Baker

Manuel Debono

R Michael Molloy

Khadiga Z Farid

Two new groups of A-21978C cyclic peptides, anhydro- and isomer-A21978C peptide derivatives, have antibacterial activity and are useful as intermediates. The two groups are prepared via transpeptidation of the parent cyclic peptides. Pharmaceutical formulations containing the new peptides as active ingredients and methods of treating infections caused by susceptible Gram-positive bacteria with the formulations are also provided. The invention also provides an antibacterial composition containing the new drug substance LY 146032 in substantially pure form.

Anhydro-and isomer-a-21978c cyclic peptides

Anhydro- and isomer-A-21978C cyclic peptides

An improved process for isolating A83543 factors from fermentation broth in which they are produced which comprises:

Process for isolating A83543 and its components

This invention relates to a new chromatographic process for purifying fermentation products, particularly the antibiotic LY146032, from fermentation broths by use of a reverse phase non-functional resin. In the process of this invention the resin is loaded with the compound in the aqueous phase, the water then is removed from the resin and the resin converted to the organic phase for the resolution step. This process is applicable to purifying compounds which are adsorbed on reverse phase non-functional resins.

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Greenwood, IN, United States of America

Patrick J Baker