Isis Innovation Limited

Oxford University Innovation Ltd

Patrick Henry Maxwell

Peter John Ratcliffe

Christopher William Pugh

Christopher Joseph Schofield

A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Antibody against human HIF hydroxylase

Assay for identifying a modulator of HIF hydroxylase

The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &#x3b1; subunits, by targeting HIF &#x3b1; for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &#x3b1; subunit sequences which may modulate this interaction.

Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto

The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial. 

HIF hydroxylase inhibitors

The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &agr; subunits, by targeting HIF &agr; for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &agr; subunit sequence which may modulate this interaction.

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Oxford, United Kingdom

Patrick Henry Maxwell