Adir Et Compagnie

Les Laboratoires Servier

Adir Et Cie

Patrick Hautefaye

Gilbert Lavielle

Alain Pierre

Ghanem Atassi

Mark Millan

Thierry Dubuffet

Laurence Kraus-Berthier

Michel Laubie

Tony Verbeuren

John Hickman

Bernard Cimetiere

Stephane Leonce

Fran&ccedil;oise Lejeune

Olivier Muller

Mauricette Brocco

Claude Cudennec

St&eacute;phane Leonce

Francedillaoise Lejeune

Camptothecin analogue compounds

Substituted hydrochromenopyrroles

Substituted hydrochromenopyridines

Bisimide compounds

A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1,

Compounds of formula (I): ##STR1## wherein: m is 0 to 3 inclusive,

A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino,

A compound of formula (I): ##STR1## in which: X represents oxygen or methylene,

New benzodioxane compounds

Compounds of formula (I): ##STR1## in which: R.sub.1 and R.sub.2, which may be identical or different, represent a linear or branched (C.sub.1 C.sub.6) alkyl radical, a substituted or unsubstituted phenyl radical, a pyridyl radical or a thienyl radical, or, with the carbon atom to which they are attached, a substituted or unsubstituted (C.sub.4 -C.sub.7) cycloalkyl ring, R.sub.3 represents

Alkenecarboxylic acid compounds

Compounds of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, m, n, and R are as defined in the Specification. Medicinal products containing the same are useful in the treatment or prevention of thrombotic afflictions due to their thromboxane A.sub.2 receptor antagonistic activity and their thromboxane A.sub.2 synthase inhibitory activity.

Pyrrolidine compounds having thromboxane A.sub.2 receptor antagonistic

The invention relates to the compounds of general formula I: ##STR1## in which: R.sub.1 represents a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkenyl radical containing from 2 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and which can bear a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidazolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,

N-(23-vincristinoyl) and N-(5'-noranhydro-23-vinblastinoyl) compounds of

The invention relates to N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid of general formula I ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkylene radical containing from 1 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and capable of bearing a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidzolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,

Growing community of inventors

Servon Brie Comte Robert, France

Patrick Hautefaye