Foundry Therapeutics, Inc.

Patrick H Ruane

Honglei Wang

Koon Kiat Teu

Jackie Joe Hancock

Daniel Boon Lim Seet

Hanson S Gifford, Iii

Karun D Naga

Jingnan Luo

Michael Steven Feldstein

Stephen W Boyd

Stephen A Boyd

Wei Li Lee

Michael Feldstein

Nassireddin Mokarram-Dorri

The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising a therapeutic agent, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.

Implantable polymer depots for the controlled release of therapeutic agents

The present technology relates to polymer implants. In some embodiments, the polymer implant may have a volume having minimum cross-sectional dimension of 400 μm. The polymer implant may be configured to be implanted within a mammalian body for at least 3 days without undergoing core acidification.

Polymer implants

The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.

Implantable depots for the controlled release of therapeutic agents

Growing community of inventors

El Dorado Hills, CA, United States of America

Patrick H Ruane