Monsanto Company

Pharmacia Corporation

Patrick H Lau

Wendell Gary Phillips

Shaun Raj Selness

Dennis K Anderson

Michael Mao

Thomas L Fevig

Win Naing

John Walker

Lisa L McDermott

Jerry D Clark

Jodi L Moe

Partha Mudipalli

Christine B Seymour

John E Baldus

Shekhar Viswanath

Jon P Lawson

Sastry A Kunda

Gopichand Yalamanchili

Kimberley C Allen

Tobin C Schilke

Gopi Yalamanchili

Todd Boehlow

Kimberly K Allen

Albert D Edeny

Daniel R Dukesherer

Dan R Dukesherer

Albert D Edney

Tom Fevig

This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R, R, R, Y, Y, Y, Y, and Yare as defined in the specification.

Process for making substituted pyrazoles

This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I):wherein R, R, R, Y, Y, Y, Y, and Yare as defined in the specification.

Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.

Synthesis of 3-carbomethoxy-4,5-dimethylthiophene

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Chesterfield, MO, United States of America

Patrick H Lau