Sanofi

Sanofi-synthelabo

Sanofi-aventis

Elf Sanofi

Other

Societe Anonyme Sanofi

Patrick Gueule

Vincenzo Proietto

Xavier Emonds-Alt

Didier Van Broeck

Jean-Philippe Ducoux

Daniel Bichon

Isabelle Grossriether

Christian Congy

Francis Barth

Murielle Rinaldi-Carmona

Nathalie Chabert

Pierre Goulaouic, Deceased

Bernard Labeeuw

Murielle Rinaldi

Joelle Taillades

Arnaud Rouquette

Xavier Edmonds-Alt

By Catherine Goulaouic, Heir

Catherine M Goulaouic, Legal Representative

Marie Bousquet, Legal Representative

By Marie Bousquet, Heir

The subject matter of the invention is compounds corresponding to formula (I), in which: Rand R, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents Rand Ris a group Y-A-R; Y is an oxygen atom or an &#x2014;S(O)&#x2014;, or &#x2014;OSOgroup; A is an unsubstituted (C-C) alkylene group; Ris an &#x2014;OR, &#x2014;CH, &#x2014;NRR, &#x2014;CONRR, &#x2014;NRCOR, &#x2014;S(O)R, or &#x2014;NRSORgroup; &#x2014;Ris a hydrogen atom or a (C-C) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I). 

Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof

The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.

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The invention relates to compounds of formula (I): Wherein X, R, R, R, Rand Rare as defined herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic use.

N-[4,5-diphenylpyrimidin-2-yl)methyl]amine derivatives, the preparation thereof and their therapeutic use

The invention relates to the compounds of formula:as well as to the salts thereof with inorganic or organic acids, to solvates thereof and/or to hydrates thereof, which have strong affinity and high selectivity for the human NKreceptors of substance P. The invention also relates to the process for preparing them, to the intermediate compounds of formula (VII) which are useful for the preparation, to pharmaceutical compositions containing them and to their fuse for the manufacture of medicinal products intended for treating any pathology in which substance P and the human NKreceptors are involved.

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them

Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them

1-Phenacyl-3-phenyl-3-(piperidylethyl)piperidine derivatives, process for the preparation thereof and pharmaceutical compositions containing them

N-(phenylacetyl)morpholine derivatives useful as NK1 receptor antagonists, a process for the preparation thereof, and pharmaceutical compositions containing them as active principle.

Morpholine derivatives, method for the production thereof and pharmaceutical preparations containing said derivatives

A method for treating diseases which involve interaction of neurokinin B with NK,receptors in humans. The method comprises administering a therapeutically effective amount of a NK,antagonist compound having the formula:

Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools

The invention relates to compounds of the formula

Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present

A compound of formula: ##STR1## in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C.sub.1 -C.sub.4)alkoxy;

Compounds which are specific antagonists of the human NK3 receptor and

Human NK.sub.3 receptor-selective antagonist compounds, method for

The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from:

Substituted heterocyclic compounds, method of preparing them and

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula ##STR1## used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P- and neurokinin-dependent pathologies.

Piperidine derivatives, process for obtaining them and pharmaceutical

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Teyran, France

Patrick Gueule