Debio Recherche Pharmaceutique S.a.

Debiopharm Research & Manufacturing Sa

Debiopharm International, S.a.

Patrick Garrouste

Roland M Wenger

Grégoire Vuagniaux

Manfred Mutter

Rafael Crabbé

Bertrand Ducrey

Robert Lysek

Marie-Anne Bardet

Olivier Turpin

Herve Porchet

Valérie Nicolas

Eija Lundstrom

Laura Novaroli Zanolari

Catherine Curdy

Frederic Heimgartner

Hervé Porchet

Frédéric Heimgarten

Frédéric Heimgartner

Pharmaceutical composition made of microparticles for the slow release of an active substance at least during a period covering the 6th month after injection of said composition, said composition comprising a group of microparticles made of a copolymer of the PLGA type which incorporate an active substance in the form of a water insoluble peptide salt; said copolymer furthermore comprising at least 75% of lactic acid and an inherent viscosity between 0.1 and 0.9 dl/g, as measured in chloroform at 25&#xb0; C. and at a polymer concentration of 0.5 g/dL; said microparticles furthermore having a size distribution defined as follows: &#x2014;D (v,0.1) is between 10 and 30 micrometers, &#x2014;D (v,0.5) is between 30 and 70 micrometers, &#x2014;D (v,0.9) is between 50 and 1 10 micrometers.

Slow release pharmaceutical composition made of microgranules

At least one embodiment of the present invention relates to new cycloundecadepsipeptide compounds and to the use of said compounds as a medicament, in particular as antiviral agents, more particularly for preventing or treating Hepatitis C infections or HCV induced disorders.

Cycloundecadepsipeptide compounds and use of said compounds as a medicament

Growing community of inventors

Saxon, Switzerland

Patrick Garrouste