Merck + Co., Inc.

Patrick G Pollard

Ravi P Nargund

Liangqin Guo

Zhixiong Ye

Iyassu K Sebhat

Feroze Ujjainwalla

Raman Kumar Bakshi

Min K Park

Brenda L Palucki

Khaled J Barakat

Qingmei Hong

Yingjie Lai

Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated piperazine derivatives as melanocortin-4 receptor agonists

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment and control of obesity, diabetes, and sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Substituted piperidines as melanocortin receptor agonists

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Oakhurst, NJ, United States of America

Patrick G Pollard