Delalande S.a.

Patrick G Guerret

Michel Langlois

Guy R Bourgery

Jean-Francois R Ancher

Alain P Lacour

Colette A Douzon

Philippe L Dostert

Phillippe L Dostert

Margherita Strolin-Benedetti

Guy M Raynaud

Bernard P Bucher

Bernard M Pourrias

Michel J Turin

Gisele C Mocquet

Alain Y Platel

Jacky A Tisne-Versailles

Alain L Nedelec

Compounds of formula: ##STR1## wherein: Ar is an aromatic group; R and R.sub.1 are H or CH.sub.3 ; A represents a nitrogenized heterocyclic radical; B is OH or forms with the adjacent CO group, either an amido group, or a carbonyloxy group; R.sub.2 and R.sub.3 are H or alkyl; m=0 or 1; and n=0, 1, 2 or 3. These compounds are useful as drugs having stimulating, protecting and/or correcting activities of the cerebral functions.

New cinnamoic compounds, the process for preparing same and the use

N-arylated oxazolidine-2-one derivatives corresponding to the formula: ##STR1## and of S(+) configuration, A representing in this case the hydroxyl radical or of R (+) configuration, A designating then the N-methylamino group, as well as the acid addition salts thereof. Application in therapeutics more particularly as monoamine oxidase inhibitors.

Optically active derivatives of N-arylated oxazolidine-2-one, the

N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones are disclosed. These compounds possess antidepressant activity.

N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use

A compound of the formula ##STR1## where R is selected from the group consisting of CH.sub.3 --CO--(CH.sub.2).sub.2 --O--, ##STR2## The compounds are useful in treating depression.

-N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and

Method of treating the central nervous system troubles such as the Parkinson's disease and the senescence troubles, generally treated by the B type monoamine oxidase inhibitors, which comprises administering internally to a human being requiring such treatment a therapeutically effective amount of N-aryl 5-aminomethyl oxazolidine-2-one derivatives.

Therapeutical use of known 5-aminomethyl oxazolidine-2-one derivatives

Compounds having analgesic activity are disclosed which have the general formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, cyclohexyl or benzyl; R is selected from the group consisting of alkyl having at least 4 carbon atoms; cyclohexyl; unsubstituted phenyl or phenyl substituted with one or more halogen atoms, methyl, methoxy, hydroxy, cyano, nitro, trifluoromethyl, carboxyl, ethoxycarbonyl, acetamido, methylsulfonyl, phenoxy, benzoyl, phenyl, .alpha.-hydroxybenzyl, cyclohexyl or carbamoyl; thienyl; pyridyl; naphthyl; naphthyl substituted with methoxy; adamantyl; and benzyl; and n is 1, 2 or 3, with the provisos that (1) when R is carboxyphenyl, benzoylphenyl, or (.alpha.-hydroxybenzyl) phenyl, n is not 3, and (2) when R is (.alpha.-hydroxy benzyl) phenyl, R.sub.1 is not benzyl, and acid addition salts thereof.

Dioxazabicyclic derivatives

There are disclosed piperidinio, piperazino and homopiperazino derivatives wherein there is N-substitution by a heterocyclic compound taken from the group benzimidazole, indole, purine or benzotriazole and to the organic or mineral acid addition salts of these derivatives. The process for preparation of such compounds and their use is also disclosed.

Piperazines and homopiperazines, N-substituted by an aromatic

N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines

3-Parahydroxyphenyl-5-methylether-2-oxazolidinone compounds

A compound having the formula ##STR1## and its pharmacologically acceptable acid addition salts. The compound is prepared by condensing N-(3,4,5-trimethoxy cinnamoyl) piperazine with N-(2-pyrrolidinone) chloroacetamide. The compounds possess peripheral and coronary vasodilatatory properties and hypotensive and antihypertensive properties.

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Rueil Malmaison, France

Patrick G Guerret