Smithkline Beecham Corporation

Access Pharmaceuticals, Inc.

Patrick F Kiser

H Mario Geysen

Allen A Thomas

A method for performing chemical synthesis includes the steps of providing a solid support having cross links, a first set of cleavable links within the cross links, and a second set of cleavable links having sites on which to perform chemistry. A first chemical is coupled to the chemistry sites, and the first chemical is reacted with a second chemical to produce a reaction product. The links are cleaved to remove the cross links and to cleave the reaction product from the solid support.

Cross linked solid supports for solid phase synthesis

Biodegradable cross-linkers are provided having a polyacid core with at least two acidic groups covalently connected to reactive groups usable to cross-link polymer filaments. Between at least one reactive group and an acidic group of the polyacid is a biodegradable region which preferably consists of a hydroxyalkyl acid ester sequence having 1, 2, 3, 4, 5 or 6 hydroxyalkyl acid ester groups. The polyacid may be attached to a water soluble region that is attached to the biodegradable region having attached reactive groups. The hydroxyalkyl acid ester group is preferably a lactate or glycolate. Polyacids include diacids, triacids, tetraacids and pentaacids, and the reactive group may contain a carbon-carbon double bond. A network of cross-linked polymer filaments having adefined biodegradation rate can be formed using the cross-linkers. The network may contain biologically active molecules, and can be in the form of a microparticle or nanoparticle, or hydrogel. The polymer filaments may be preformed polymer filaments of polynucleic acids, polypeptides, proteins or carbohydrates. The cross-linkers may be copolymerized with charged monomers such as acrylic monomers containing charged groups. Applications of the cross-linkers and network include controlled release of drugs and cosmetics, tissue engineering, wound healing, hazardous waste remediation, metal chelation, swellable devices for absorbing liquids and prevention of surgical adhesions.

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Durham, NC, United States of America

Patrick F Kiser