University of Utah Research Foundation

Dsm IP Assets B.v.

Dsm Biomedical Inc.

Kiser, Patrick F.

Patrick F Kiser

R Tyler McCabe

Margaret N Kiser

Theodore Henry Albright

Meredith Roberts Clark

Robert S Ward

Shanger Wang

Li Li

Durgaprasad Chalasani

Russell John Stewart

Kavita Gupta

Julie I Jay

Richard Scott Stayner

Rachna Rastogi

Justin Thomas Clark

R Tyler Mccabe

Todd Joseph Johnson

Namdev Shelke

The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the contents of the lumen to the outer surface, and the first segment comprises a polymer selected from the group consisting of a hydrophilic, semi-permeable elastomer and a hydrophobic elastomer. The lubricant may be an aqueous lubricant. The present technology further provides an intravaginal device including a solid first segment that includes a hydrophilic semi-permeable elastomer, an outer surface and an aqueous lubricant, wherein the first segment is configured to deliver the aqueous lubricant to the outer surface.

Intravaginal devices for controlled delivery of lubricants

Intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): Also, method comprising administering one or more pharmaceutically active substances to a patient in need thereof.

Intravaginal ring comprising polyurethane composition for drug delivery

The invention is directed to an intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I):  The invention is further directed to administering one or more pharmaceutically active substances to a patient in need thereof.

Crosslinked proteins, proteins and polymers, and polymers and methods of making the same are disclosed. In one illustrative embodiment, a method is provided comprising the steps of attaching a chelator to one or more polymers; creating a coordination complex between the first protein, the second protein, and a metal ion; and crosslinking the first and second proteins by exposing the coordination complex to an oxidant.

Crosslinking within coordination complexes

Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety and wherein the crosslinking moiety is formed from a reaction between a boronic acid moiety and a hydroxamic acid moiety. Also, described are methods of making and using such polymeric compositions.

Polymeric compositions and methods of making and using thereof

Growing community of inventors

Chicago, IL, United States of America

Patrick F Kiser