Bio-rad Laboratories, Inc.

Beckman Instruments, Inc.

Genetic Systems Corporation

Patrick F Coleman

Peilin Chen

Michael I Watkins

Nobuo Monji

Carol-Ann Cole

Lawrence Blecka

James J Blake

Daming Shan

David J Marrujo

John P Montana

Rose M Cernosek

Charles C Walbourn

Peter Chong-Dug Su

Hao Yu

Peter Su

Gregory A Marr

Xiaoyun Yang

Richard Bruehl

Larry Blecka

Alice Kamp Goshorn

The present invention relates to peptides that are derived from HSV-2 glycoprotein G2 and represent HSV-2 type-specific epitopes. The present invention also provides for compositions comprising these peptides for type-specific serological diagnosis of HSV-2 infection. Methods of using these peptides for type-specific detection of HSV-2 antibodies and differentiation of HSV-2 viral infection from HSV-1 and other herpes family viral infections are further provided.

HSV-2 type-specific immunoassays using glycoprotein G2 peptides

Novel polypeptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of exposure of a human host to the virus. Of particular interest is the use of polypeptides in screening blood products.

Synthetic antigen for the detection of antibodies immunoreactive with HIV virus

Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine thiol groups protected. When deprotected, the peptides have enhanced immunoreactivity. The peptides are particularly useful for detecting antibodies or antigens associated with retroviruses, including the clinically important lymphotropic retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II.

Cysteine thiol-protected peptides for use in immunoassays

A two part peroxide/chromogen reagent for use in peroxidase labeled binding assays which is stable for at least about 24 hours is disclosed. The reagent is provided as two components, the first component preferably incorporating a peroxide dissolved in a first solvent, and the second component preferably having a chromogenic substance dissolved in a second solvent where the two components can be mixed within about 48 hours of colorimetric detection of an enzyme immunoassay.

Stable two-part chromogen substrate

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Edmonds, WA, United States of America

Patrick F Coleman