Seattle Biomedical Research Institute

Rhode Island Hospital

US Government As Represented by the Secretary of the Army

Seattle Children's Hospital

Other

Philadelphia Health and Education Corporation

The United States of America As Represented by the Army

Patrick Emmet Duffy

Michal Fried

Jonathan Kurtis

Dipak Kumar Raj

Jennifer Frances Friedman

Christian Parcher Nixon

Jason P Wendler

Andrew V Oleinikov

Igor Bacik

Theonest K Mutabingwa

Susan Francis

Urszula Krzych

Donald G Heppner

Vladislav A Malkov

Stefan H I Kappe

Lawrence W Bergman

Nunzio Biagio Sgroi

Jason W Wendler

Alice Tarun

The invention provides compositions and methods for preventing or reducing the severity of malaria.

Vaccine for falciparum malaria

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The invention provides isolated liver stagepolypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stagepolypeptides of the invention, compositions comprising one or more liver stagepolypeptides of the invention, methods for inducing an immune response against the liver stagepolypeptides, and methods for treating and diagnosing liver stage malaria.

The invention provides isolated placentalpolypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placentalpolypeptides of the invention, compositions comprising one or more placentalpolypeptides of the invention, methods for inducing an immune response against the placentalpolypeptides, and methods for treating and diagnosing placental malaria.

Malaria vaccines

The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.

Plasmodium liver stage antigens

A recycling game apparatus includes a toy vehicle having a plurality of bins for holding game pieces and having a card caddy thereon. A deck of cards is supported in the toy vehicle card caddy along with a plurality of game pieces with each game piece having a shaped emulative of a recycling member and stored in a marked bin. The game pieces can be moved into and out of the bins in playing the game. Each card in the deck of cards has information concerning one recycling item which is emulative of at least one game piece, such as aluminum, newspaper, glass, or plastic. Each toy vehicle plurality of bins may be marked with indicia to indicate aluminum, paper, glass, plastic, or trash. The toy vehicle is used to store the game with cards and pieces as well as used in playing the game.

Recycling game

A traction device for providing relief to the spinal column in which a person is suspended from the midsection over a pair of support pads. The angular position of each support pad is independently adjustable, thereby enabling the stretching effect of the traction device to be specifically tailored for the particular injury being treated. A control mechanism for adjusting and locking the angular position of each pad, and a pad with a generally saddle-shaped profile is described.

Asymetrically adjustable traction device

Growing community of inventors

Washington, DC, United States of America

Patrick Emmet Duffy