Medtronic Vascular, Inc.

Medtronic, Inc.

Boston Scientific Scimed, Inc.

Millipede, Inc.

Transvascular, Inc.

Other

Patrick Edward Macaulay

Joshua Makower

J Christopher Flaherty

Randall T Lashinski

Matthew Rust

Philip Christopher Evard

Jason Brian Whitt

John T Garibotto

Timothy R Machold

Richard Glenn

Stephen J Peter

Terry Wayne Daniels

Michael Lee

Kristian Kristoffersen

Kris Kristoffersen

Niall F Duffy

Russell J Redmond

Claude A Vidal

Patrick Griffin

Joshua J Dwork

Thomas Banks

Evelyn Birmingham

Marc A Anderson

Robert H Murray

Adam Shipley

Dustin Thompson

Susheel Deshmukh

David R Tholfsen

Marc Jensen

David Clarke

Gavin Kenny

Mark Casley

Kate Corish

John P Shanahan

Alan Robert Selfridge

Deirdre Bridget McGowan Smyth

Constantin Ciobanu

Donna Barrett

Margaret W Tumas

Bernard Patrick Mulvihill

Paul Cassidy

Sameer Upadhyaya

Ak Masud

A K M Masud

Gustaf L P Belt

Luke McCartney

Theodore Charles Lamson

Padraig Savage

Hubert K Yeung

Nathan K Brown

K Angela Macfarlane

Robert C Colloton

Kenny Dwight Bruner

Avram Scheiner

John E Burnes

Alex T Roth

Kenneth C Gardeski

Kevin M Mauch

Mary M Morris

Don H Tran

Finn Olavi Rinne

Walter Bruszewski

Ruth N Klepfer

Gianfranco Pellegrini

Michele Lee Silver

Ahmed M Elmouelhi

Asha Shrinivas Nayak

Jeremy Daniel Johnson

D H Perkins

Nathan Wiemeyer

John Milroy

Brian R Beckey

Hubert K Young

Richard Spork

Isaac Han Joon Kim

Nathan B Wiemeyer

Peter Stephen

Paul Casidy

John Thomas Garibotto

Christopher J c/o Proteus Biomedical Inc Flaherty

Systems and methods for delivering and implanting heart valves are disclosed. The delivery systems can include an integrated introducer. The integrated introducer can include a sheath having an inner diameter that is smaller than the outer diameter of a delivery capsule of the delivery system and an outer diameter that is approximately equal to the outer diameter of the delivery capsule. The integrated introducer can include a hub having a hemostatic seal. The hub can have a locking mechanism configured to fix the integrated introducer in place on the delivery system.

Delivery system with inline sheath

Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.

Valve replacement using moveable restraints and angled struts

An elastic percutaneous elastic introducer sheath is disclosed which can locally expand and reduce to accommodate a transcatheter medical device. The elastic introducer sheath includes a non-circumferentially continuous elastic frame, a liner, and a jacket.

Elastic introducer sheath

Systems, devices and methods related to various heart valve implants and for delivery of those heart valve implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. Anchors secure the implant to tissue and collars are used to decrease the angle between the struts and contract the frame. The implant thus expands from a first size inside of a delivery catheter, to a second and larger deployed size inside the heart to engage and anchor with the tissue, and then to a third and contracted size to re-size the annulus and/or provide a secure fit for a replacement heart valve. Various delivery systems including imaging capabilities for precise delivery, positioning and anchoring of the various implants are further described.

Implantable device and delivery system for reshaping a heart valve annulus

A tray and packaging system for a prosthetic valve delivery system permits conversion from a storage and/or shipping configuration to a set up and preparation configuration. In a first configuration, a delivery system can be supported by first and second main trays with the elongate catheter of the delivery system arranged to extend linearly from the first main tray to the second main tray, and in a second configuration, the delivery system can be supported by the first and second main trays with the elongate catheter of the delivery system turned back in a U-shaped manner with the deployment portion of the delivery system positioned to the side of the control handle portion of the delivery system.

Delivery catheter system with micro and macro movement control

Systems, devices and methods related to various heart valve implants and for delivery of those implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. The implant is secured to tissue with anchors that can rotate without axial advancement to engage tissue while drawing the implant closer to the tissue. Collars are used to decrease the angle between struts of a frame to contract the implant. The implants can include a rotatable shaft, such as a threaded shaft, located internally to an axially translatable collar. Rotation of the shaft transmits force to the collar to cause the collar to translate axially, closing the angle of adjacent struts and decreasing the width of the implant and thus of the annulus. The implants can be delivered, secured and contracted via a catheter. The implants are repositionable and retrievable via catheter.

Methods related to delivery of various heart valve implants are described. The implant may be delivered using an ultrasound imaging delivery system. The ultrasound imaging delivery system may be used to deliver a variety of different devices, including mitral valve reshaping devices, mitral valve replacement valves, and others. A deployment catheter carrying an implant having a tissue anchor is advanced to a deployment site in a heart. An imaging element is positioned adjacent the implant and a relationship between the tissue anchor and an anatomical landmark in the heart is visualized. The implant is then attached by driving the tissue anchor into tissue in the heart.

Methods for delivery of heart valve devices using intravascular ultrasound imaging

Excessive dilation of the annulus of a mitral valve may lead to regurgitation of blood during ventricular contraction. This regurgitation may lead to a reduction in cardiac output. Disclosed are systems and methods relating to an implant configured for reshaping a mitral valve. The implant comprises a plurality of struts with anchors for tissue engagement. The implant is compressible to a first, reduced diameter for transluminal navigation and delivery to the left atrium of a heart. The implant may then expand to a second, enlarged diameter to embed its anchors to the tissue surrounding and/or including the mitral valve. The implant may then contract to a third, intermediate diameter, pulling the tissue radially inwardly, thereby reducing the mitral valve and lessening any of the associated symptoms including mitral regurgitation.

Adjustable endolumenal implant for reshaping the mitral valve annulus

Growing community of inventors

San Jose, CA, United States of America

Patrick Edward Macaulay